|
KMID : 0859320060240040248
|
|
Journal of the Korean Society for Therapeutic Radiology and Oncology
2006 Volume.24 No. 4 p.248 ~ p.254
|
|
|
Intensity Modulated Whole Pelvic Radiotherapy in Patients with Cervix Cancer: Analysis of Acute Toxicity
|
|
Choi Young-Min
Lee Hyung-Sik
Hur Won-Joo
Cha Moon-Seok
Kim Hyun-Ho
|
|
|
Abstract
|
|
|
Purpose: To evaluate acute toxicities in cervix cancer patients receiving intensity modulated whole pelvic
radiation therapy (IM-WPRT).
Materials and Methods: Between August 2004 and April 2006, 17 patients who underwent IM-WPRT were
analysed. An intravenous contrast agent was used for radiotherapy planning computed tomography (CT). The
central clinical target volume (CTV) included the primary tumor, uterus, vagina, and parametrium. The nodal
CTV was defined as the lymph nodes larger than 1 cm seen on CT and the contrased-enhanced pelvic
vessels. The planning target volume (PTV) was the 1-cm expanded volume around the central CTV, except for
a 5-mm expansion from the posterior vagina, and the nodal PTV was defined as the nodal CTV plus a 1.5 cm
margin. IM-WPRT was prescribed to deliver a dose of 50 Gy to more than 95% of the PTV. Acute toxicity was
assessed with common toxicity criteria up to 60 days after radiotherapy.
Results: Grade 1 nausea developed in 10 (58.9%) patients, and grade 1 and 2 diarrhea developed in 11
(64.7%) and 1 (5.9%) patients, respectively. No grade 3 or higher gastrointestinal toxicity was seen. Leukopenia,
anemia, and thrombocytopenia occurred in 15 (88.2%). 7 (41.2%), and 2 (11.8%) patients, respectively, as
hematologic toxicities. Grade 3 leukopenia developed in 2 patients who were treated with concurrent chemoradiotherapy.
Conclusion: IM-WPRT can be a useful treatment for cervix cancer patients with decreased severe acute
toxicities and a resultant improved compliance to whole pelvic irradiation.
|
|
|
KEYWORD
|
|
|
Cervix cancer, Intensity modulated radiotherapy, Acute toxicity
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|
|